{"created":"2023-05-15T12:36:42.683902+00:00","id":61,"links":{},"metadata":{"_buckets":{"deposit":"b2cf7879-df08-41fb-b838-589f98c9e8a3"},"_deposit":{"created_by":2,"id":"61","owners":[2],"pid":{"revision_id":0,"type":"depid","value":"61"},"status":"published"},"_oai":{"id":"oai:tamagawa.repo.nii.ac.jp:00000061","sets":["6:18:21:54"]},"author_link":["1855","1856","1857","1858","1859"],"control_number":"61","item_2_alternative_title_12":{"attribute_name":"英訳タイトル","attribute_value_mlt":[{"subitem_alternative_title":"Changes in Adipicytokine Secretion of 3T3―L1 Pre-adipocytic Cells During Differentiation Cultured with Berberine"}]},"item_2_biblio_info_4":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2019-03-30","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"3","bibliographicPageEnd":"21","bibliographicPageStart":"15","bibliographic_titles":[{"bibliographic_title":"玉川大学農学部研究教育紀要"}]}]},"item_2_description_2":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"本研究では、高グルコース培地を用いたマウス3T3―L1 細胞の脂肪細胞分化誘導におけるベルベリンの作用を検討した。ベルベリンは脂肪細胞分化誘導初期にグルコース消費を亢進した。ベルベリンは細胞内の脂質合成に関する転写因子PPAR γ発現を抑制し、グリセロール―3―リン酸脱水素酵素（GPDH）活性の発現も強く抑制した。14 日間分化誘導した3T3―L1細胞にはトリグリセリドが蓄積したが、ベルベリン添加によってトリグリセリド蓄積は3分の1にまで減少した。アディポカインアレーを用いて培養上清中のサイトカイン分析を行ったところ、ベルベリンはレプチンおよびレジスチン分泌を強く抑制した。これらの結果から、ベルベリンは糖尿病を含むメタボリックシンドロームの改善に役立つ作用を有することが期待される。","subitem_description_type":"Abstract"}]},"item_2_publisher_13":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"玉川大学","subitem_publisher_language":"ja"}]},"item_2_source_id_5":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"2432-2164","subitem_source_identifier_type":"ISSN"}]},"item_2_source_id_6":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA12766546","subitem_source_identifier_type":"NCID"}]},"item_2_version_type_7":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"新本, 洋士"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"伊藤, 愛美"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"星﨑, 玲奈"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"山口, 貴士"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"長縄, 康範"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-06-26"}],"displaytype":"detail","filename":"2_2018_15-21.pdf","filesize":[{"value":"2.5 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"2_2018_15-21.pdf","url":"https://tamagawa.repo.nii.ac.jp/record/61/files/2_2018_15-21.pdf"},"version_id":"01b66a89-7526-435e-8b33-27e1c19d406f"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"脂肪細胞"},{"subitem_subject":"分化誘導"},{"subitem_subject":"ベルベリン"},{"subitem_subject":"アディポサイトカイン"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper"}]},"item_title":"分化誘導したマウス前駆脂肪細胞3T3―L1のサイトカイン分泌におけるベルベリンの作用","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"分化誘導したマウス前駆脂肪細胞3T3―L1のサイトカイン分泌におけるベルベリンの作用","subitem_title_language":"ja"}]},"item_type_id":"2","owner":"2","path":["54"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2019-06-24"},"publish_date":"2019-06-24","publish_status":"0","recid":"61","relation_version_is_last":true,"title":["分化誘導したマウス前駆脂肪細胞3T3―L1のサイトカイン分泌におけるベルベリンの作用"],"weko_creator_id":"2","weko_shared_id":-1},"updated":"2023-07-12T01:00:40.794943+00:00"}