| Item type |
紀要論文 / Departmental Bulletin Paper(1) |
| 公開日 |
2018-06-21 |
| タイトル |
|
|
タイトル |
集中が記憶に及ぼす影響 |
|
言語 |
ja |
| 言語 |
|
|
言語 |
jpn |
| キーワード |
|
|
主題 |
hippocampus |
| キーワード |
|
|
主題 |
STDP |
| キーワード |
|
|
主題 |
acetylcholine |
| 資源タイプ |
|
|
資源タイプ |
departmental bulletin paper |
| 著者 |
杉﨑, えり子
福島, 康弘
相原, 威
|
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
The hippocampus located inside the temporal lobe plays an important role in learning and memory, thus, it has been widely experimented by researchers using hippocampal tissues. Especially, the synaptic plasticity, the foundational phenomenon for learning and memory observed at the cell level, is largely investigated and clarified in details. Meanwhile, acetylcholine （ACh） is released from the cholinergic terminals that project from the medial septum to the hippocampus during attentional processes, resulting in the enhancement of synaptic plasticity. In this review, what kinds of ACh effects influence on the spike timing-dependent plasticity （STDP）, and which ACh receptors on which neurons highly contribute to the STDP are mainly addressed. In addition, underlying mechanisms of the enhancement of STDP induction in the presence of ACh is discussed as well; the direction of STDP is regulated by muscarinic ACh receptors while the amplitude of that is sensitively fine-tuned by nicotinic ACh receptors. Finally, a new finding of the relationship between ACh and the dynamics of membrane potentials during the synaptic changes led by the STDP-inducing stimuli is introduced as one of the related factors for the enhancement of STDP induction in the presence of ACh. |
| 書誌情報 |
玉川大学脳科学研究所紀要
号 11,
p. 29-35,
発行日 2018-03-11
|
| ISSN |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
1882-7160 |
| 著者版フラグ |
|
| 出版者 |
|
|
出版者 |
玉川大学 |
|
言語 |
ja |
21_2018_29-35.pdf (370.8 kB)
