WEKO3
アイテム
NON-STATIONARY NOISE ANALYSIS AND SYNAPTIC TRANSMISSION
http://hdl.handle.net/11078/47
http://hdl.handle.net/11078/47836647ae-a062-4318-a189-4c59f6d29fc5
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
3_2013_51-74.pdf (406.4 kB)
|
|
| Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||||
|---|---|---|---|---|---|---|---|---|
| 公開日 | 2013-10-10 | |||||||
| タイトル | ||||||||
| タイトル | NON-STATIONARY NOISE ANALYSIS AND SYNAPTIC TRANSMISSION | |||||||
| 言語 | en | |||||||
| 言語 | ||||||||
| 言語 | eng | |||||||
| キーワード | ||||||||
| 主題 | non-stationary noise analysis | |||||||
| キーワード | ||||||||
| 主題 | glutamate receptor | |||||||
| キーワード | ||||||||
| 主題 | single channnel | |||||||
| キーワード | ||||||||
| 主題 | Purkinje cell | |||||||
| 資源タイプ | ||||||||
| 資源タイプ | departmental bulletin paper | |||||||
| 著者 |
Kojima, Hiroshi
× Kojima, Hiroshi
|
|||||||
| 抄録 | ||||||||
| 内容記述タイプ | Abstract | |||||||
| 内容記述 | Non-stationary noise analysis is one of the most significant methods to estimate single channel conductance of receptor channels that mediate postsynaptic currents at the synapses in the central nervous system. In the present article, the principle of the peak-scaled fluctuation analysis is described in the context of synaptic transmission between neurons. Furthermore, this fluctuation analysis is applied to glutamate receptor channnel in order to investigate the properties of AMPA receptor channels which underlay long-term change in synaptic strength, which is thought to be substrate of memory and learning in the brain, observed in cerebellar Purkinje cell. Whole cell patch clamp technique was used to measure the synaptic currents from Purkinje cell by parallel fiber activation. The decay phases of the postsynaptic currents were approximated by a single exponential function. The mean current and variance relationship was fitted with the parabolic curves to estimate the single channel conductance. It was suggested that no change in single channel conductance was observed before and during LTD. | |||||||
| 書誌情報 |
玉川大学工学部紀要 巻 2013, 号 48, p. 51-74, 発行日 2013-03-31 |
|||||||
| ISSN | ||||||||
| 収録物識別子タイプ | ISSN | |||||||
| 収録物識別子 | 0371-5981 | |||||||
| 著者版フラグ | ||||||||
| 出版者 | ||||||||
| 出版者 | 玉川大学 | |||||||
| 言語 | ja | |||||||
