| Item type |
紀要論文 / Departmental Bulletin Paper_08(1) |
| 公開日 |
2023-12-05 |
| タイトル |
|
|
タイトル |
海馬歯状回のスパイク依存可塑性に対するアセチルコリン効果 |
|
言語 |
ja |
| タイトル |
|
|
タイトル |
The effect of acetylcholine on spike timing-dependent plasticity induced in the hippocampal dentate gyrus |
|
言語 |
en |
| 言語 |
|
|
言語 |
jpn |
| キーワード |
|
|
言語 |
en |
|
主題 |
hippocampus |
| キーワード |
|
|
言語 |
en |
|
主題 |
dentate gyrus |
| キーワード |
|
|
言語 |
en |
|
主題 |
granule cell |
| キーワード |
|
|
言語 |
en |
|
主題 |
medial perforant path |
| キーワード |
|
|
言語 |
en |
|
主題 |
lateral perforant path |
| キーワード |
|
|
言語 |
en |
|
主題 |
spike timing-dependent plasticity |
| キーワード |
|
|
言語 |
en |
|
主題 |
acetylcholine |
| 資源タイプ |
|
|
資源タイプ |
departmental bulletin paper |
| ID登録 |
|
|
ID登録 |
10.15045/0002000167 |
|
ID登録タイプ |
JaLC |
| 著者 |
杉﨑,えり子
立脇,志穂
礒村,宜和
相原,威
|
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
Spatial and non-spatial information is known to flow into granule cells (GC) in the hippocampal dentate gyrus via the medial and lateral perforant path (MPP/LPP) respectively. At both sites, spike timing-dependent plasticity (STDP) was induced, however, how acetylcholine (ACh), a neuromodulator released when attentional processes are made, influences on STDP induction is unclear. To clarify the dependence of ACh on inducing STDP, patch-clamp recordings were made to the soma of GCs using rat hippocampal slices. As the results, STDPs at the MPP and LPP synapses were shifted to long-term potentiation direction along with ACh concentration by BCM curve. One of the mechanisms seemed to be an elevation of baseline amplitude during STDP-inducing stimuli allowing postsynaptic Ca2+ level increased. In addition, STDP at the LPP synapse was smaller than that of at the MPP. These results suggest that ACh may contribute to highlighting important information when spatial and non-spatial information is provided simultaneously. |
|
言語 |
en |
| 書誌情報 |
玉川大学工学部紀要
号 58,
p. 33-38,
発行日 2023-04-20
|
| ISSN |
|
|
収録物識別子タイプ |
PISSN |
|
収録物識別子 |
0371-5981 |
| 著者版フラグ |
|
| 出版者 |
|
|
出版者 |
玉川大学 |
|
言語 |
ja |
3-2023_33-38.pdf
